2ah2

Publication Abstract from PubMed
Sialidases are a superfamily of sialic-acid-releasing enzymes that are of significant interest due to their implication as virulence factors in the pathogenesis of a number of diseases. However, extensive studies of viral and microbial sialidases have failed to provide a comprehensive picture of their mechanistic properties, in part because the structures of competent enzyme-substrate complexes and reaction intermediates have never been described. Here we report these structures for the Trypanosoma cruzi trans-sialidase (TcTS), showing that catalysis by sialidases occurs via a similar mechanism to that of other retaining glycosidases, but with some intriguing differences that may have evolved in response to the substrate structure.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure
2AH2 is a 1 chain structure of sequence from Trypanosoma cruzi. This structure supersedes the now removed PDB entry 1s0k. Full crystallographic information is available from OCA.

Reference
Page seeded by OCA on Mon Feb 16 17:08:11 2009